HbA1c and Neuropathic Pain in Type 2 Diabetes: a Case-Control Study With the S-LANSS Questionnaire

Published on February 25, 2026

Exp Clin Endocrinol Diabetes. 2026 Feb 24. doi: 10.1055/a-2821-0293. Online ahead of print.

ABSTRACT

BACKGROUND: Neuropathic pain is a frequent and disabling complication of type 2 diabetes mellitus. Although poor glycemic control is known to contribute to diabetic neuropathy, its specific relationship with painful manifestations remains incompletely characterized.

OBJECTIVE: To evaluate the association between hemoglobin A1c levels and the presence of neuropathic pain in patients with type 2 diabetes mellitus.

METHODS: A cross-sectional analytical study was conducted in 172 adults with type 2 diabetes mellitus attending outpatient clinics at a tertiary hospital in northern Peru. Neuropathic pain was assessed using the validated Spanish version of the Self-Administered Leeds Assessment of Neuropathic Symptoms and Signs questionnaire. Glycemic control was evaluated using hemoglobin A1c, analyzed both as a continuous variable and dichotomized at seven percent. Clinical, metabolic, and demographic variables were compared between patients with and without neuropathic pain. Associations were examined using Poisson regression with robust variance and logistic regression, estimating crude and adjusted effect measures with ninety-five percent confidence intervals.

RESULTS: Neuropathic pain was identified in fifty percent of participants. Patients with neuropathic pain showed higher hemoglobin A1c values and a greater proportion of values equal to or above seven percent. In adjusted models, elevated hemoglobin A1c remained independently associated with neuropathic pain, both when analyzed as a dichotomous and as a continuous variable. Dyslipidemia and hypertension also showed independent associations.

CONCLUSION: Higher hemoglobin A1c levels are independently associated with neuropathic pain in patients with type 2 diabetes mellitus, underscoring the importance of sustained glycemic control.

PMID:41734808 | DOI:10.1055/a-2821-0293

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