News & Publications

Acta Anaesthesiol Scand. 2026 Oct;70(9):e70329. doi: 10.1111/aas.70329.ABSTRACTBACKGROUND: Clonidine, an alpha-2 receptor agonist, has been explored as a potential analgesic in postoperative pain management, but its efficacy and safety profile remain unclear. The aim of this scoping review was to present the evidence on the use of intravenous clonidine in postoperative pain management.METHODS: Thi

Tissue Cell. 2026 Aug 21;104(Pt 2):103888. doi: 10.1016/j.tice.2026.103888. Online ahead of print.ABSTRACTBone marrow-derived mesenchymal stem cells (BMSCs) have demonstrated therapeutic promise for tissue repair, owing to their multipotent differentiation and immunomodulatory properties. However, their therapeutic efficacy is frequently constrained by poor survival and inadequate integration into

Biomed Pharmacother. 2026 Aug 27;203:119889. doi: 10.1016/j.biopha.2026.119889. Online ahead of print.ABSTRACTBACKGROUND: Chronic pain remains challenging to treat, with current therapies offering incomplete relief and significant side effects. This narrative review examines cyclodextrins (CDs) beyond their conventional excipient role, focusing on their emerging function as membrane-active modulat

Eur Neurol. 2026 Aug 28:1-16. doi: 10.1159/000552973. Online ahead of print.ABSTRACTBACKGROUND: The pathogenesis of diabetic neuropathic pain (DNP) remains unclear, with neuroinflammation mediated by abnormal TNF-α/NF-κB pathway activation being a key factor. This study aims to elucidate how this pathway contributes to DNP.METHODS: miR-33a-5p levels were measured via qPCR in the serum of diabetic

Turk J Anaesthesiol Reanim. 2026 Aug 28;54(4):323-330. doi: 10.4274/TJAR.2026.262403.ABSTRACTOBJECTIVE: Thoracotomy produces severe postoperative pain that limits deep breathing and coughing and may worsen recovery. Opioid-centred regimens can cause adverse effects; pre-emptive multimodal analgesia may reduce central sensitisation and opioid use.METHODS: In this randomized, active-controlled, asse

Now Available: How to Make Team Science a Success - Lessons Learned and Reflections from the RE-JOIN ConsortiumWatch the full presentation now in the Media CenterSpeaking at the 2026 PURPOSE Annual Meeting, Nele Haelterman, PhD, Team Science Center Lead for the RE-JOIN Consortium, presents an operational framework for managing complex, transdisciplinary team science in pain and addiction research.

NIH (including help desks) will be closed on Monday, October 12, 2026 for the federal holiday (Columbus Day). If a grant application due date falls on a federal holiday, the application deadline is automatically extended to the next business day.

JMIR Res Protoc. 2026 Aug 27;15:e92566. doi: 10.2196/92566.ABSTRACTBACKGROUND: Cancer-related pain remains highly prevalent and frequently undertreated despite advances in oncological therapies and analgesic strategies. Multidisciplinary approaches are recommended to optimize complex cancer pain management and integrate supportive care; however, robust real-world evidence evaluating their measurab

In 2025, we announced an updated NIH Policy on Foreign Subawards (NOT-OD-25-104) and introduced the Collaborative International Research application and award structure using the PF5 activity code (NOT-OD-25-155) which was implemented earlier this year.  The multi-project PF5 structure accommodates individual components for international projects which, if selected for funding, become separate dir

Nearly two decades ago, we began allowing more than one researcher to be designated as program director/principal investigator (PD/PI) on a single grant award. The multiple PD/PI (MPI) model can provide important benefits, including giving each investigator credit as an NIH-designated PD/PI, but it is not required to conduct collaborative or team science. It is intended to supplement—not replace—t

Notice NOT-GM-26-020 from the NIH Guide for Grants and Contracts

Notice NOT-GM-26-014 from the NIH Guide for Grants and Contracts

Notice NOT-GM-26-013 from the NIH Guide for Grants and Contracts

Notice NOT-DA-26-016 from the NIH Guide for Grants and Contracts

Notice NOT-OD-26-113 from the NIH Guide for Grants and Contracts

Front Pain Res (Lausanne). 2026 Aug 12;7:1896306. doi: 10.3389/fpain.2026.1896306. eCollection 2026.ABSTRACTChronic pain and fatigue have resisted pharmacological resolution for two decades despite detailed mechanistic characterisation of nociceptive circuits. This perspective argues that the problem is not insufficient data but a mismatch between the level at which the dominant model operates and

J Pain Res. 2026 Aug 22;19:624864. doi: 10.2147/JPR.S624864. eCollection 2026.ABSTRACTChronic pain is a highly prevalent and clinically heterogeneous condition, and its underlying mechanisms remain incompletely understood. The lack of objective, clinically validated biomarkers has hindered diagnostic stratification, mechanistic insight, and treatment evaluation. Diffusion magnetic resonance imagin

Brain Sci. 2026 Aug 21;16(8):896. doi: 10.3390/brainsci16080896.ABSTRACTChronic pain is a major global health burden and often remains difficult to treat with current therapies, which frequently provide incomplete relief and may cause systemic side effects. As essential organelles in eukaryotic cells, mitochondria facilitate ATP synthesis and serve as key regulators of calcium homeostasis and apop

Neurochem Int. 2026 Aug 26:106249. doi: 10.1016/j.neuint.2026.106249. Online ahead of print.ABSTRACTNeuropathic pain (NP) is a debilitating chronic condition whose molecular mechanisms remain incompletely understood, limiting the development of effective disease-modifying therapies. Lactylation, a lactate-derived post-translational modification of histone and non-histone lysine residues, has recen

New Video Available: Pain Mechanisms and TreatmentWatch the full presentation now in the Media CenterIn Episode 7 of the Exploring Pain series, host Laura Wandner, PhD, sits down with Ted Price, PhD, Director of the Center for Advanced Pain Studies at UT Dallas, to explore how molecular neuroscience is advancing precision pain medicine. Price highlights single-cell transcriptomic and proteomic fin