News & Publications

Spine J. 2026 Jul 16:S1529-9430(26)00584-X. doi: 10.1016/j.spinee.2026.07.006. Online ahead of print.ABSTRACTBACKGROUND CONTEXT: Mechanical chronic low back pain (CLBP) associated with lumbar multifidus muscle dysfunction is a major cause of long-term disability. Available nonoperative and interventional treatments often provide limited and transient benefit. Restorative neurostimulation is intend

Front Pain Res (Lausanne). 2026 Jul 2;7:1797161. doi: 10.3389/fpain.2026.1797161. eCollection 2026.ABSTRACTBurn injuries are among the most frequent traumas associated with human activity and primarily affect the skin. Unlike other forms of tissue injury, burns produce a unique combination of extensive tissue destruction, rapid release of damage-associated signals, and profound alterations in cuta

Front Pain Res (Lausanne). 2026 Jul 2;7:1852975. doi: 10.3389/fpain.2026.1852975. eCollection 2026.ABSTRACTOBJECTIVE: This study systematically evaluated the effects of Tai Chi on pain, functional disability, and sleep quality in patients with chronic non-specific low back pain (CNLBP).METHODS: We searched CNKI, WanFang, VIP, China Biology Medicine Database, PubMed, Web of Science, Embase, and the

bioRxiv [Preprint]. 2026 Jul 6:2026.07.01.735618. doi: 10.64898/2026.07.01.735618.ABSTRACTThe kappa opioid receptor (KOR) has emerged as a promising, nonaddictive analgesic target, yet the neural mechanisms underlying KOR inhibition of pain are not entirely understood. Here, we provide converging evidence that KOR expressed on spinal neurons inhibits acute pain. We demonstrate that pharmacological

Front Digit Health. 2026 Jul 2;8:1833918. doi: 10.3389/fdgth.2026.1833918. eCollection 2026.ABSTRACTINTRODUCTION: Interventional pain management is characterised by substantial variability in clinical response, durability of benefit and risk of adverse events, which limits traditional decision-making approaches based on empirical procedure selection. In this context, artificial intelligence has be

J Clin Gastroenterol. 2026 Jul 16. doi: 10.1097/MCG.0000000000002427. Online ahead of print.ABSTRACTOBJECTIVE: This study aimed to identify if pain catastrophizing is a mediator between pain intensity and functioning (functional disability and sleep), as well as mental health (anxiety and depression) in patients with pain-predominant disorders of gut-brain interaction (DGBI).BACKGROUND: Pediatric

Res Nurs Health. 2026 Jul 16. doi: 10.1002/nur.70105. Online ahead of print.ABSTRACTThis randomized controlled trial aimed to determine the effect of music played during intrauterine device (IUD) insertion on perceived pain, state anxiety, and satisfaction levels. The study was conducted with 70 women who applied to a maternal and child health and family planning center and were randomly assigned

Nat Commun. 2026 Jul 15. doi: 10.1038/s41467-026-74144-3. Online ahead of print.ABSTRACTChronic pain caused by peripheral nerve injury involves altered spinal pain transduction, where enhanced excitatory and/or reduced inhibitory pathways can drive pain. The cellular transcriptional changes that sustain entrenched neuropathic pain remain poorly understood. Here we use single-nucleus and spatial tr

BMJ Support Palliat Care. 2026 Jul 15:spcare-2026-006282. doi: 10.1136/spcare-2026-006282. Online ahead of print.ABSTRACTOBJECTIVES: The continual evaluation of quality indicators (QIs) for cancer pain management is essential to maintaining and improving its quality. However, free-text notes in electronic medical records (EMRs) must be reviewed to accurately assess pain management QIs, and the hea

Arch Phys Med Rehabil. 2026 Jul 15:S0003-9993(26)00815-4. doi: 10.1016/j.apmr.2026.07.006. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the mid- and long-term benefits of percutaneous electrical nerve stimulation applied to the radial nerve, combined with exercise, in patients with chronic lateral elbow pain, focusing on pain intensity, pain-related disability, psychological outcomes, and

Complement Ther Med. 2026 Jul 15;101:103403. doi: 10.1016/j.ctim.2026.103403. Online ahead of print.ABSTRACTBACKGROUND: Photobiomodulation with low-level laser therapy has been investigated as an adjunctive strategy for postoperative pain and wound healing after cesarean section, but the available trials use heterogeneous protocols and outcomes.OBJECTIVE: To evaluate the effects of low-level laser

Clin Pract Cases Emerg Med. 2025 Aug;9(3):264-267. doi: 10.5811/cpcem.43494.ABSTRACTINTRODUCTION: Buprenorphine is used for treating opioid use disorder, but its role as an analgesic in the emergency department (ED) is frequently overlooked. Emerging evidence indicates that, at low doses, it can be used safely and advantageously as an alternative to full-agonist opioids for treating acute pain.CAS

Curr Neuropharmacol. 2026 Jul 10. doi: 10.2174/011570159X487795260629095134. Online ahead of print.ABSTRACTThe mitochondrial Permeability Transition Pore (mPTP) has been implicated in cell death, energy failure, and oxidative stress. Emerging evidence suggests that mPTP may also contribute to the development and maintenance of chronic pain, although evidence remains limited and the underlying mech

Front Pain Res (Lausanne). 2026 Jul 1;7:1864829. doi: 10.3389/fpain.2026.1864829. eCollection 2026.ABSTRACTINTRODUCTION: Refractory neuropathic pelvic pain significantly impairs quality of life and is notoriously difficult to treat. We present the case of a 63-year-old woman who developed severe pelvic pain following emergency open thoracic aortic aneurysm repair. Despite extensive pharmacologic,

Prz Menopauzalny. 2026 Mar;25(1):45-51. doi: 10.5114/pm.2026.161669. Epub 2026 May 11.ABSTRACTChronic pelvic pain (CPP) affects approximately 26% of women and significantly impacts quality of life. Common causes include dysmenorrhea and pelvic floor dysfunction. Transcutaneous electrical nerve stimulation (TENS) is widely used for pain relief to inhibit pain transmission and stimulate endogenous o

Digit Health. 2026 Jul 14;12:20552076261467865. doi: 10.1177/20552076261467865. eCollection 2026 Jan-Dec.ABSTRACTBACKGROUND: Chronic pain affects up to 20% of the population and often results in significant distress, disability, and reduced quality of life. Despite compelling evidence for behavioural treatments, treatment access remains limited. To improve access, a digital behavioural treatment f

Front Genet. 2026 Jul 2;17:1852317. doi: 10.3389/fgene.2026.1852317. eCollection 2026.ABSTRACTOBJECTIVES: Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder caused by mutations in NTRK1 that is characterized by pain insensitivity, anhidrosis, and recurrent fever. While genetic testing is the gold standard for CIPA diagnosis, the complexity of NTRK1 varia

Front Pharmacol. 2026 Jul 1;17:1865248. doi: 10.3389/fphar.2026.1865248. eCollection 2026.ABSTRACTPain is a complex sensory and affective experience regulated by distributed neural circuits that integrate internal physiological states with external stimuli. Orexinergic neurons, a widely projecting neuronal population within the lateral hypothalamus (LH), play a central role in this process. This r

Front Surg. 2026 Jul 1;13:1833183. doi: 10.3389/fsurg.2026.1833183. eCollection 2026.ABSTRACTBACKGROUND: The purpose of this study was to analyze the correlation between the cross-sectional area (CSA) and density of lumbar core muscles and residual chronic low back pain (rCLBP) after Posterior Lumbar Interbody Fusion (PLIF).METHODS: In this retrospective study, patients who underwent PLIF surgery

Front Immunol. 2026 Jul 1;17:1869876. doi: 10.3389/fimmu.2026.1869876. eCollection 2026.ABSTRACTINTRODUCTION: Chronic primary pain conditions, including fibromyalgia, affect up to 10% of the population, yet their pathophysiology is unexplored and the treatment is insufficient. Chronic stress is a key etiological factor and is known to modulate microglial function, partly via the CX3CR1 fractalkine