News & Publications

Nat Commun. 2026 Jul 15. doi: 10.1038/s41467-026-74144-3. Online ahead of print.ABSTRACTChronic pain caused by peripheral nerve injury involves altered spinal pain transduction, where enhanced excitatory and/or reduced inhibitory pathways can drive pain. The cellular transcriptional changes that sustain entrenched neuropathic pain remain poorly understood. Here we use single-nucleus and spatial tr

BMJ Support Palliat Care. 2026 Jul 15:spcare-2026-006282. doi: 10.1136/spcare-2026-006282. Online ahead of print.ABSTRACTOBJECTIVES: The continual evaluation of quality indicators (QIs) for cancer pain management is essential to maintaining and improving its quality. However, free-text notes in electronic medical records (EMRs) must be reviewed to accurately assess pain management QIs, and the hea

Arch Phys Med Rehabil. 2026 Jul 15:S0003-9993(26)00815-4. doi: 10.1016/j.apmr.2026.07.006. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the mid- and long-term benefits of percutaneous electrical nerve stimulation applied to the radial nerve, combined with exercise, in patients with chronic lateral elbow pain, focusing on pain intensity, pain-related disability, psychological outcomes, and

Complement Ther Med. 2026 Jul 15;101:103403. doi: 10.1016/j.ctim.2026.103403. Online ahead of print.ABSTRACTBACKGROUND: Photobiomodulation with low-level laser therapy has been investigated as an adjunctive strategy for postoperative pain and wound healing after cesarean section, but the available trials use heterogeneous protocols and outcomes.OBJECTIVE: To evaluate the effects of low-level laser

Clin Pract Cases Emerg Med. 2025 Aug;9(3):264-267. doi: 10.5811/cpcem.43494.ABSTRACTINTRODUCTION: Buprenorphine is used for treating opioid use disorder, but its role as an analgesic in the emergency department (ED) is frequently overlooked. Emerging evidence indicates that, at low doses, it can be used safely and advantageously as an alternative to full-agonist opioids for treating acute pain.CAS

Curr Neuropharmacol. 2026 Jul 10. doi: 10.2174/011570159X487795260629095134. Online ahead of print.ABSTRACTThe mitochondrial Permeability Transition Pore (mPTP) has been implicated in cell death, energy failure, and oxidative stress. Emerging evidence suggests that mPTP may also contribute to the development and maintenance of chronic pain, although evidence remains limited and the underlying mech

Front Pain Res (Lausanne). 2026 Jul 1;7:1864829. doi: 10.3389/fpain.2026.1864829. eCollection 2026.ABSTRACTINTRODUCTION: Refractory neuropathic pelvic pain significantly impairs quality of life and is notoriously difficult to treat. We present the case of a 63-year-old woman who developed severe pelvic pain following emergency open thoracic aortic aneurysm repair. Despite extensive pharmacologic,

Prz Menopauzalny. 2026 Mar;25(1):45-51. doi: 10.5114/pm.2026.161669. Epub 2026 May 11.ABSTRACTChronic pelvic pain (CPP) affects approximately 26% of women and significantly impacts quality of life. Common causes include dysmenorrhea and pelvic floor dysfunction. Transcutaneous electrical nerve stimulation (TENS) is widely used for pain relief to inhibit pain transmission and stimulate endogenous o

Digit Health. 2026 Jul 14;12:20552076261467865. doi: 10.1177/20552076261467865. eCollection 2026 Jan-Dec.ABSTRACTBACKGROUND: Chronic pain affects up to 20% of the population and often results in significant distress, disability, and reduced quality of life. Despite compelling evidence for behavioural treatments, treatment access remains limited. To improve access, a digital behavioural treatment f

Front Genet. 2026 Jul 2;17:1852317. doi: 10.3389/fgene.2026.1852317. eCollection 2026.ABSTRACTOBJECTIVES: Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder caused by mutations in NTRK1 that is characterized by pain insensitivity, anhidrosis, and recurrent fever. While genetic testing is the gold standard for CIPA diagnosis, the complexity of NTRK1 varia

Front Pharmacol. 2026 Jul 1;17:1865248. doi: 10.3389/fphar.2026.1865248. eCollection 2026.ABSTRACTPain is a complex sensory and affective experience regulated by distributed neural circuits that integrate internal physiological states with external stimuli. Orexinergic neurons, a widely projecting neuronal population within the lateral hypothalamus (LH), play a central role in this process. This r

Front Surg. 2026 Jul 1;13:1833183. doi: 10.3389/fsurg.2026.1833183. eCollection 2026.ABSTRACTBACKGROUND: The purpose of this study was to analyze the correlation between the cross-sectional area (CSA) and density of lumbar core muscles and residual chronic low back pain (rCLBP) after Posterior Lumbar Interbody Fusion (PLIF).METHODS: In this retrospective study, patients who underwent PLIF surgery

Front Immunol. 2026 Jul 1;17:1869876. doi: 10.3389/fimmu.2026.1869876. eCollection 2026.ABSTRACTINTRODUCTION: Chronic primary pain conditions, including fibromyalgia, affect up to 10% of the population, yet their pathophysiology is unexplored and the treatment is insufficient. Chronic stress is a key etiological factor and is known to modulate microglial function, partly via the CX3CR1 fractalkine

J Oral Rehabil. 2026 Jul 15. doi: 10.1111/joor.70271. Online ahead of print.ABSTRACTOBJECTIVE: This systematic review aimed to evaluate the effectiveness of myofascial release therapy (MFR) on pain in patients affected by myogenous temporomandibular disorders (TMD).METHODS: PubMed, Scopus, and Web of Science were searched from inception until 31 January 2026, to identify RCTs including patients af

Aust Endod J. 2026 Jul 15. doi: 10.1111/aej.70107. Online ahead of print.ABSTRACTAchieving profound local anaesthesia during mandibular molar root canal treatment can be challenging. This study evaluated procedural pain and supplemental anaesthesia used, considering endodontic diagnosis and buccal bone morphology. Seventy-seven patients undergoing primary root canal treatment completed a post-trea

As part of NIH’s ongoing efforts to modernize its web presence and make information easier to find in one place, our NIH Funding social media accounts have transitioned to NIH Innovates on X and LinkedIn. You can expect the same information on grants and funding, plus more updates from NIH’s institutes, centers, and offices.What stays the sameYou’ll continue to get timely updates on grants policie

If you’re planning to apply for an NIH fellowship (F), career development award (K), or training grant (T), staying informed about recent NIH efforts to centralize peer review can help you understand how your application may be assigned and reviewed. As supporting and sustaining the future research workforce remains a top priority for NIH leadership and reflected in the NIH Unified Funding Strateg

Background:The problem of a sharp increase in pain after resolution of a nerve block, known as rebound pain, has been increasingly recognized. It is currently unknown whether rebound pain simply reflects the unmasking of untreated, residual surgical pain, or if it represents a de novo hyperalgesic state driven by a mechanistic resetting of pain thresholds in response to regional anesthesia. In thi

Pharmacol Rep. 2026 Jul 15. doi: 10.1007/s43440-026-00880-4. Online ahead of print.ABSTRACTBACKGROUND: Postherpetic neuralgia (PHN) is a chronic neuropathic pain condition that develops following herpes zoster, yet the molecular mechanisms underlying the transition from acute herpetic pain to chronic pain remain unclear. Brain-derived neurotrophic factor (BDNF)-TrkB signaling is implicated in cent

Pain Rep. 2026 Jul 10;11(4):e1463. doi: 10.1097/PR9.0000000000001463. eCollection 2026 Aug.ABSTRACTINTRODUCTION: Chronic pain (CP) can profoundly strain family systems, yet few population studies have explored prevalence and population dynamics of CP with high impact on families.OBJECTIVES: Examining prevalence and phenomenological characteristics of chronic pain with high impact on the families o