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Lancet Healthy Longev. 2026 May 28:100851. doi: 10.1016/j.lanhl.2026.100851. Online ahead of print.ABSTRACTBACKGROUND: Ageing survivors of childhood cancer experience pain that substantially affects daily activities and health. We investigated the contribution of pain to frailty development or progression in survivors.METHODS: In this analysis of the St Jude Lifetime Cohort (SJLIFE), adult survivo

Anesth Analg. 2026 May 28. doi: 10.1213/ANE.0000000000008078. Online ahead of print.ABSTRACTBACKGROUND: Inadequate pain management affects over half of the 230 million major surgeries performed annually. Preemptive analgesia aims to prevent peripheral and central sensitization. Dexmedetomidine (DEX) offers non-opioid analgesia and opioid-sparing effects. This study evaluated the efficacy of preemp

J Pain. 2026 May 27:106329. doi: 10.1016/j.jpain.2026.106329. Online ahead of print.ABSTRACTVisceral pain remains a major clinical challenge, often resistant to conventional analgesics. Sigma-1 receptor (σ1R) antagonists enhance opioid antinociception in somatic and neuropathic pain, yet their role in visceral nociception remains unclear. Here we investigated whether σ1R blockade potentiates the a

Cell Signal. 2026 May 27:112623. doi: 10.1016/j.cellsig.2026.112623. Online ahead of print.ABSTRACTChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common urological disorder characterized by persistent pelvic pain or discomfort as its core symptom. It is frequently accompanied by lower urinary tract symptoms and significant psychological burden, severely impacting patients' quality

J Surg Res. 2026 May 28;324:144-154. doi: 10.1016/j.jss.2026.05.003. Online ahead of print.ABSTRACTINTRODUCTION: Amputation causes significant reorganization in the motor and somatosensory cortex. Phantom limb pain (PLP) is a disorder characterized by pain in the missing limb that can persist for years. The treatment of PLP includes both pharmacological and nonpharmacological options. The study ai

Explore (NY). 2026 May 25;22(4):103453. doi: 10.1016/j.explore.2026.103453. Online ahead of print.ABSTRACTINTRODUCTION: LI4 acupressure is a commonly used non-pharmacological method for labor pain relief; however, variations in application methods, duration, and frequency limit the development of standardized protocols. Our study aimed to combine the studies in literature examining the effects of

Musculoskelet Sci Pract. 2026 May 22;84:103587. doi: 10.1016/j.msksp.2026.103587. Online ahead of print.ABSTRACTBACKGROUND: Superficial heat is recommended in acute low back pain (LBP) to reduce pain and disability. Exercise is recommended in chronic LBP, but its relevance in acute LBP remains debated. Heatwrap could potentiate the effect of exercise in acute LBP, and this combination might help p

PLoS One. 2026 May 28;21(5):e0349031. doi: 10.1371/journal.pone.0349031. eCollection 2026.ABSTRACTINTRODUCTION: Unplanned pregnancy remains a critical public health issue in Brazil that affects up to 65% of women in some regions and increases the incidence of both unsafe abortions and maternal mortality. Although the copper intrauterine device (IUD) is a highly effective, long-acting contraceptive

Rehabil Psychol. 2026 May 28. doi: 10.1037/rep0000669. Online ahead of print.ABSTRACTPURPOSE/OBJECTIVE: This study examined how resilience, conceptualized at both the within-person (state-like) and between-person (trait-like) levels, relates to psychological and social adjustment among individuals with spinal cord injury and chronic pain.RESEARCH METHOD/DESIGN: A prospective observational study co

Cell Rep. 2026 May 28;45(6):117442. doi: 10.1016/j.celrep.2026.117442. Online ahead of print.ABSTRACTThe dorsal root ganglion (DRG) is examined for sex-dependent phenotypes in sensory neurons, satellite glial cells (SGCs), and local macrophages following traumatic nerve injury and during natural pain resolution. Systematic analysis of 7,495 DRG immunofluorescence images and 62 transcriptomes revea

Neuromodulation. 2026 May 7:S1094-7159(26)00115-7. doi: 10.1016/j.neurom.2026.04.017. Online ahead of print.ABSTRACTOBJECTIVES: Painful peripheral neuropathies (PN) are highly prevalent and often refractory to pharmacological treatment. Given the emerging evidence of central nervous system involvement in painful PN, noninvasive brain stimulation (NIBS) techniques have gained attention as potential

J Back Musculoskelet Rehabil. 2026 May 28:10538127261451359. doi: 10.1177/10538127261451359. Online ahead of print.ABSTRACTBackground Plantar fasciitis (PF) is a leading cause of heel pain, impairing function and quality of life. While manual therapy is widely used, comparative evidence between specific techniques remains limited.Objective This study aimed to compare the effects of articulatory ma

BJS Open. 2026 May 12;10(3):zrag035. doi: 10.1093/bjsopen/zrag035.ABSTRACTBACKGROUND: Postoperative pain remains a major challenge following major abdominal surgery. Noise in the operating room is a modifiable stressor, and the efficacy of targeted noise isolation requires prospective investigation. This study investigated the effects of intraoperative noise isolation on the incidence of moderate-

Abstract The ability of human caregivers to decode and respond to the distress information encoded in a baby's cries is essential for the baby's survival. What are the factors that influence this aptitude, and how is this represented in the brain? Although previous neuroimaging studies have shown that hearing cries activates a set of brain areas that drive caregiver response behaviors, they have m

Psychol Health Med. 2026 May 28:1-21. doi: 10.1080/13548506.2026.2680327. Online ahead of print.ABSTRACTChronic pain among people of color is influenced by biological, structural, and social forces. While network models have been applied to chronic pain symptoms, research on resource disparities often isolates factors such as income, failing to account for how these systemic resources interact as

J Biophotonics. 2026 Jun;19(6):e70299. doi: 10.1002/jbio.70299.ABSTRACTApproximately 80% of the world population has had, has, or will have back pain. The aim of this study is to investigate the acute and chronic effects of the synergistic application of photobiomodulation with mechanical systems on low back pain. Patients with low back pain were randomly distributed into 5 groups: 1- Vacuum thera

Cochrane Database Syst Rev. 2026 May 28;5:CD008626. doi: 10.1002/14651858.CD008626.pub4.ABSTRACTRATIONALE: Botulinum toxin type A (BoNT-A) intramuscular injections are commonly administered for neck pain unresponsive to other therapies, but the benefit-harm profile remains uncertain.OBJECTIVES: To assess the benefits and harms of intramuscular BoNT-A injection for people with subacute to chronic n

Notice NOT-CA-26-012 from the NIH Guide for Grants and Contracts

Notice NOT-CA-26-011 from the NIH Guide for Grants and Contracts

As part of NIH’s continued efforts to increase the transparency of the NIH research portfolio, data on the sex, race, ethnicity, and age of participants in fiscal year (FY) 2025 NIH-supported clinical research are now available. The FY25 data were presented at the 64th meeting of the Advisory Committee on Research on Women’s Health (ACRWH) on April 7, 2026. Data from previous years are available o