News & Publications

Curr Pharm Des. 2026 Oct 5. doi: 10.2174/0113816128510427260927100857. Online ahead of print.ABSTRACTBACKGROUND: The global opioid crisis has intensified interest in non-opioid and opioid-sparing analgesic strategies, including cannabinoids. Despite the expanding legal landscape for cannabis and a rapidly growing cannabinoid market, the clinical evidence for cannabinoid use in acute pain managemen

Curr Pharm Biotechnol. 2026 Oct 5. doi: 10.2174/0113892010424007260928171201. Online ahead of print.ABSTRACTINTRODUCTION/OBJECTIVE: Chronic pain and opioid-related harm intersect through overlapping biological, behavioral, and clinical pathways. This narrative review presents a framework linking dopamine homeostasis, opioid-risk reduction, and objective cognitive testing in precision pain and addi

Eur J Pain. 2026 Oct;30(9):e70418. doi: 10.1002/ejp.70418.This journal recently published a paper by Naylor et al. (2026) entitled ‘Variations in current and desired limb perception in complex regional pain syndrome’. Misperceptions and delusions about one's body are a striking feature of many neurological and psychiatric conditions, from phantom limbs in amputees to body image distortions in eati

CNS Neurol Disord Drug Targets. 2026 Oct 6. doi: 10.2174/0118715273492918261001111401. Online ahead of print.ABSTRACTNeurodegenerative disorders, including Alzheimer's Disease (AD), Parkinson's Disease (PD), and Neuropathic Pain (NP), share overlapping molecular and cellular mechanisms that contribute to progressive neuronal dysfunction, neuroinflammation, and impaired neural repair. Although thes

Musculoskeletal Care. 2026 Dec;24(4):e70273. doi: 10.1002/msc.70273.ABSTRACTBACKGROUND: Chronic widespread pain (CWP) affects around 10% of adults and is more prevalent in women. The impact of CWP on daily life varies, as do coping strategies.OBJECTIVE: To describe women's different ways of coping with CWP.METHODS: A descriptive, qualitative phenomenographic study. Semi-structured interviews were

Front Med (Lausanne). 2026 Sep 28;13:1911807. doi: 10.3389/fmed.2026.1911807. eCollection 2026.ABSTRACTINTRODUCTION: Chronic pain is a significant global public health challenge. There is substantial evidence supporting the benefits of mindfulness-based interventions for chronic pain. Mindfulness-Based Pain Management (MBPM) is an 8-week mindfulness-based behavioral intervention program designed t

Clin J Sport Med. 2026 Oct 13. doi: 10.1097/JSM.0000000000001519. Online ahead of print.ABSTRACTOBJECTIVE: Patellofemoral pain syndrome (PFPS) is common among runners and is linked to biomechanical dysfunctions that increase patellofemoral joint stress. Gait retraining has been proposed to redistribute this loading, but the effectiveness of different retraining strategies and their long-term impac

Neuromolecular Med. 2026 Oct 12;28(1):55. doi: 10.1007/s12017-026-08953-6.ABSTRACTPhysical activity is known to ameliorate neuropathic pain (NP); however, the underlying mechanisms, particularly those involving long non-coding RNAs (lncRNAs) in the hippocampus, remain poorly understood. In this study, we assessed the impact of swimming training on NP in a mouse model of sciatic nerve injury (SNI),

Spinal Cord. 2026 Oct 12. doi: 10.1038/s41393-026-01286-y. Online ahead of print.ABSTRACTSTUDY DESIGN: Cross-sectional natural language processing (NLP) study of publicly available Reddit data.OBJECTIVES: To map the thematic structure and affective tone of neuropathic pain discourse among Reddit users self-identifying with spinal cord injury (SCI) or clinically overlapping cord and cauda pathology

Signal Transduct Target Ther. 2026 Oct 13;11(1):444. doi: 10.1038/s41392-026-02931-x.ABSTRACTPain is a multifaceted sensory and emotional experience that profoundly affects human health and quality of life. It functions as a double-edged sword: while acute pain serves as a protective warning signal, chronic pain compromises physiological and psychological well-being. Pain is now widely regarded as

bioRxiv [Preprint]. 2026 Aug 12:2026.08.06.742589. doi: 10.64898/2026.08.06.742589.ABSTRACTSpinal cord stimulation (SCS) is an established therapy for neuropathic pain, typically delivered at either low (60 Hz) or high (1 kHz) frequencies, with analgesic effects largely dependent on active stimulation. Here, we investigated whether combined-frequency SCS produces sustained analgesia beyond stimula

bioRxiv [Preprint]. 2026 Aug 12:2026.08.06.743081. doi: 10.64898/2026.08.06.743081.ABSTRACTSensory neurons have been increasingly recognized as vital contributors to deep tissue function. However, how these specialized neurons contribute to salivary gland function remains largely undefined. Here, we uncover a role for trigeminal somatosensory afferents in salivary gland perception and function usi

J Plast Reconstr Aesthet Surg. 2026 Sep 24;123:71-80. doi: 10.1016/j.bjps.2026.09.039. Online ahead of print.ABSTRACTBACKGROUND: Neuropathic pain following traumatic brachial plexus injury (BPI) is common, severe, and frequently refractory to pharmacologic therapy, particularly in case of root avulsion and deafferentation. Reconstructive procedures such as nerve grafting and nerve transfer have be

Schizophr Res. 2026 Oct 7;298:34-43. doi: 10.1016/j.schres.2026.09.039. Online ahead of print.ABSTRACTBACKGROUND: Abnormal pain processing and somatosensory aversions are underappreciated clinical features of early onset psychosis (EOP). We aimed to identify their clinical, neurobehavioral, and brain circuit level correlates.METHODS: Clinical assessments and child (ages 12-18 years) and parent-rep

J Am Med Dir Assoc. 2026 Oct 7;27(11):106432. doi: 10.1016/j.jamda.2026.106432. Online ahead of print.ABSTRACTOBJECTIVE: Pain is common among long-term care (LTC) residents, and acetaminophen is often recommended as first-line therapy. We aimed to determine whether regularly scheduled acetaminophen, compared with any comparator, improves pain outcomes in LTC.DESIGN: Systematic review and meta-anal

J Med Internet Res. 2026 Oct 7;28:e95903. doi: 10.2196/95903.ABSTRACTBACKGROUND: Chronic musculoskeletal pain is a major public health problem, and access to continuous, long-term care remains challenging. Digital health interventions may extend care beyond conventional settings; however, their comparative effects across delivery modalities and core therapeutic components remain uncertain.OBJECTIV

Neurol Neurochir Pol. 2026 Oct 8. doi: 10.5603/pjnns.111689. Online ahead of print.ABSTRACTINTRODUCTION: Neuropathic pain is caused by a lesion or disease of the somatosensory nervous system. Pharmacotherapy remains the primary treatment for this condition, although non-pharmacological modalities such as physical and psychological therapy are also recommended.STATE OF THE ART: Due to the limited e

Pain Manag. 2026 Oct 8:1-3. doi: 10.1080/17581869.2026.2744709. Online ahead of print.1. Introduction1.1. Pain beyond the biomedical modelBiomedical accounts that treat pain as a signal of tissue damage or dysfunction explain only part of what patients report. The International Association for the Study of Pain (IASP) defines pain as “an unpleasant sensory and emotional experience associated with,

Psychol Health Med. 2026 Oct 7:1-14. doi: 10.1080/13548506.2026.2738082. Online ahead of print.ABSTRACTThis randomized controlled trial evaluated the effects of interactive and non-interactive virtual reality (VR) distraction on pain, anxiety, procedure-related emotional behaviour, and parent and nurse satisfaction during venipuncture in school-age children. The study was conducted in the phleboto

Domestic Annual Reports for the reporting period of October 1, 2025, through September 30, 2026, are due to the NIH Office of Laboratory Animal Welfare (OLAW) by December 1, 2026, for domestic institutions with an approved Domestic Animal Welfare Assurance. The Domestic Annual Report to OLAW webpage includes the domestic Annual Report form and an optional Sample Addendum to report Changes in Veter