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bioRxiv [Preprint]. 2026 Aug 12:2026.08.06.742589. doi: 10.64898/2026.08.06.742589.ABSTRACTSpinal cord stimulation (SCS) is an established therapy for neuropathic pain, typically delivered at either low (60 Hz) or high (1 kHz) frequencies, with analgesic effects largely dependent on active stimulation. Here, we investigated whether combined-frequency SCS produces sustained analgesia beyond stimula

bioRxiv [Preprint]. 2026 Aug 12:2026.08.06.743081. doi: 10.64898/2026.08.06.743081.ABSTRACTSensory neurons have been increasingly recognized as vital contributors to deep tissue function. However, how these specialized neurons contribute to salivary gland function remains largely undefined. Here, we uncover a role for trigeminal somatosensory afferents in salivary gland perception and function usi

J Plast Reconstr Aesthet Surg. 2026 Sep 24;123:71-80. doi: 10.1016/j.bjps.2026.09.039. Online ahead of print.ABSTRACTBACKGROUND: Neuropathic pain following traumatic brachial plexus injury (BPI) is common, severe, and frequently refractory to pharmacologic therapy, particularly in case of root avulsion and deafferentation. Reconstructive procedures such as nerve grafting and nerve transfer have be

Schizophr Res. 2026 Oct 7;298:34-43. doi: 10.1016/j.schres.2026.09.039. Online ahead of print.ABSTRACTBACKGROUND: Abnormal pain processing and somatosensory aversions are underappreciated clinical features of early onset psychosis (EOP). We aimed to identify their clinical, neurobehavioral, and brain circuit level correlates.METHODS: Clinical assessments and child (ages 12-18 years) and parent-rep

J Am Med Dir Assoc. 2026 Oct 7;27(11):106432. doi: 10.1016/j.jamda.2026.106432. Online ahead of print.ABSTRACTOBJECTIVE: Pain is common among long-term care (LTC) residents, and acetaminophen is often recommended as first-line therapy. We aimed to determine whether regularly scheduled acetaminophen, compared with any comparator, improves pain outcomes in LTC.DESIGN: Systematic review and meta-anal

J Med Internet Res. 2026 Oct 7;28:e95903. doi: 10.2196/95903.ABSTRACTBACKGROUND: Chronic musculoskeletal pain is a major public health problem, and access to continuous, long-term care remains challenging. Digital health interventions may extend care beyond conventional settings; however, their comparative effects across delivery modalities and core therapeutic components remain uncertain.OBJECTIV

Neurol Neurochir Pol. 2026 Oct 8. doi: 10.5603/pjnns.111689. Online ahead of print.ABSTRACTINTRODUCTION: Neuropathic pain is caused by a lesion or disease of the somatosensory nervous system. Pharmacotherapy remains the primary treatment for this condition, although non-pharmacological modalities such as physical and psychological therapy are also recommended.STATE OF THE ART: Due to the limited e

Pain Manag. 2026 Oct 8:1-3. doi: 10.1080/17581869.2026.2744709. Online ahead of print.1. Introduction1.1. Pain beyond the biomedical modelBiomedical accounts that treat pain as a signal of tissue damage or dysfunction explain only part of what patients report. The International Association for the Study of Pain (IASP) defines pain as “an unpleasant sensory and emotional experience associated with,

Psychol Health Med. 2026 Oct 7:1-14. doi: 10.1080/13548506.2026.2738082. Online ahead of print.ABSTRACTThis randomized controlled trial evaluated the effects of interactive and non-interactive virtual reality (VR) distraction on pain, anxiety, procedure-related emotional behaviour, and parent and nurse satisfaction during venipuncture in school-age children. The study was conducted in the phleboto

Domestic Annual Reports for the reporting period of October 1, 2025, through September 30, 2026, are due to the NIH Office of Laboratory Animal Welfare (OLAW) by December 1, 2026, for domestic institutions with an approved Domestic Animal Welfare Assurance. The Domestic Annual Report to OLAW webpage includes the domestic Annual Report form and an optional Sample Addendum to report Changes in Veter

Schmerz. 2026 Oct 8. doi: 10.1007/s00482-026-00978-x. Online ahead of print.ABSTRACTBACKGROUND: Chronic pain is highly relevant for health services. Scientific data show the relevance of psychosocial factors; however, these factors are often ignored in primary diagnostics and therapy.AIM: The aim of the study was to explore, through semi-structured interviews, which critical life events as well as

Anesth Analg. 2026 Oct 7. doi: 10.1213/ANE.0000000000008324. Online ahead of print.ABSTRACTBACKGROUND: Chronic postsurgical pain (CPSP) is a debilitating complication following posterior lumbar surgery, often exacerbated by retraction-induced paraspinal muscle injury. While deep neuromuscular blockade (DNMB) optimizes surgical conditions, its ability to mitigate this mechanical injury and prevent

Notice NOT-AI-26-004 from the NIH Guide for Grants and Contracts

New Video Available: HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) - Question & AnswerWatch the Q&A now in the Media CenterAlex H. Tuttle and Erin Burke Quinlan presented on the upcoming NIH HEAL Initiative Whole Joint Health Program (R61/R33) (PAR-27-045), and answered questions.Presenters:Alex H. Tuttle, PhD | Acting Deputy Branch Chief, Basic and Mechanistic Rese

Front Public Health. 2026 Sep 21;14:1919984. doi: 10.3389/fpubh.2026.1919984. eCollection 2026.ABSTRACTChronic pain is a public health issue that affects a substantial proportion of adults and limits life, work, and social participation. Although pain is understood as a multidimensional experience shaped by biological, psychological, social, and contextual factors, chronic pain care is often organ

Front Med (Lausanne). 2026 Sep 21;13:1918770. doi: 10.3389/fmed.2026.1918770. eCollection 2026.ABSTRACTBACKGROUND: The epidemiological link between dry eye disease (DED) and chronic pain is established, yet a shared genetic etiology remains uncertain.METHODS: Utilizing GWAS summary data, we applied linkage disequilibrium score regression (LDSC) to determine genetic correlation between DED and mult

Pain Med. 2026 Oct 5:pnag133. doi: 10.1093/pm/pnag133. Online ahead of print.ABSTRACTBACKGROUND: Chronic musculoskeletal pain is a major problem for military beneficiaries, with incident rates increasing more than 3-fold from 2009 to 2018. Guidelines recommend nonpharmacologic, holistic approaches within a stepped care framework. Two promising strategies, Empowered Relief (ER), a lower-intensity s

Nat Commun. 2026 Sep 3;17(1):10503. doi: 10.1038/s41467-026-76982-7.ABSTRACTThe spinal cord dorsal horn (DH) integrates sensory processing but undergoes critical plasticity following nerve injury, leading to mechanical allodynia, or "touch-evoked pain". It has been proposed that after nerve injury, innocuous sensory neurons gain access to nociceptive-specific (NS) circuits in the DH due to altered

The NIH Comparative Genomics Resource (CGR) provides a centralized repository of tools and resources that aims to maximize the potential of eukaryotic research organisms and their genomic data for biomedical discovery. By bringing high-quality data and common tools together, CGR addresses some key challenges in genomics science, including inconsistencies in data quality and data siloed in separate

J Perianesth Nurs. 2026 Oct 5:S1089-9472(26)00501-0. doi: 10.1016/j.jopan.2026.09.004. Online ahead of print.ABSTRACTEffective pain assessment during the perioperative period is a crucial responsibility for nurses. However, relying solely on numerical rating scales may not fully capture the complexity of postoperative pain experiences. This article offers perioperative nurses evidence-based guidan