News & Publications

JMIR Res Protoc. 2026 Aug 27;15:e92566. doi: 10.2196/92566.ABSTRACTBACKGROUND: Cancer-related pain remains highly prevalent and frequently undertreated despite advances in oncological therapies and analgesic strategies. Multidisciplinary approaches are recommended to optimize complex cancer pain management and integrate supportive care; however, robust real-world evidence evaluating their measurab

In 2025, we announced an updated NIH Policy on Foreign Subawards (NOT-OD-25-104) and introduced the Collaborative International Research application and award structure using the PF5 activity code (NOT-OD-25-155) which was implemented earlier this year.  The multi-project PF5 structure accommodates individual components for international projects which, if selected for funding, become separate dir

Nearly two decades ago, we began allowing more than one researcher to be designated as program director/principal investigator (PD/PI) on a single grant award. The multiple PD/PI (MPI) model can provide important benefits, including giving each investigator credit as an NIH-designated PD/PI, but it is not required to conduct collaborative or team science. It is intended to supplement—not replace—t

Notice NOT-GM-26-020 from the NIH Guide for Grants and Contracts

Notice NOT-GM-26-014 from the NIH Guide for Grants and Contracts

Notice NOT-GM-26-013 from the NIH Guide for Grants and Contracts

Notice NOT-DA-26-016 from the NIH Guide for Grants and Contracts

Notice NOT-OD-26-113 from the NIH Guide for Grants and Contracts

Front Pain Res (Lausanne). 2026 Aug 12;7:1896306. doi: 10.3389/fpain.2026.1896306. eCollection 2026.ABSTRACTChronic pain and fatigue have resisted pharmacological resolution for two decades despite detailed mechanistic characterisation of nociceptive circuits. This perspective argues that the problem is not insufficient data but a mismatch between the level at which the dominant model operates and

J Pain Res. 2026 Aug 22;19:624864. doi: 10.2147/JPR.S624864. eCollection 2026.ABSTRACTChronic pain is a highly prevalent and clinically heterogeneous condition, and its underlying mechanisms remain incompletely understood. The lack of objective, clinically validated biomarkers has hindered diagnostic stratification, mechanistic insight, and treatment evaluation. Diffusion magnetic resonance imagin

Brain Sci. 2026 Aug 21;16(8):896. doi: 10.3390/brainsci16080896.ABSTRACTChronic pain is a major global health burden and often remains difficult to treat with current therapies, which frequently provide incomplete relief and may cause systemic side effects. As essential organelles in eukaryotic cells, mitochondria facilitate ATP synthesis and serve as key regulators of calcium homeostasis and apop

Neurochem Int. 2026 Aug 26:106249. doi: 10.1016/j.neuint.2026.106249. Online ahead of print.ABSTRACTNeuropathic pain (NP) is a debilitating chronic condition whose molecular mechanisms remain incompletely understood, limiting the development of effective disease-modifying therapies. Lactylation, a lactate-derived post-translational modification of histone and non-histone lysine residues, has recen

New Video Available: Pain Mechanisms and TreatmentWatch the full presentation now in the Media CenterIn Episode 7 of the Exploring Pain series, host Laura Wandner, PhD, sits down with Ted Price, PhD, Director of the Center for Advanced Pain Studies at UT Dallas, to explore how molecular neuroscience is advancing precision pain medicine. Price highlights single-cell transcriptomic and proteomic fin

Physiother Theory Pract. 2026 Aug 24:1-18. doi: 10.1080/09593985.2026.2716384. Online ahead of print.ABSTRACTBACKGROUND: Nonspecific low back pain (NSLBP) has profound adverse impacts at both the individual level, such as pain and dysfunction, as well as the health system level, including high care costs. Prior research suggests that physiotherapists adhere to some aspects of NSLBP clinical practi

Hemoglobin. 2026 Aug 24:1-10. doi: 10.1080/03630269.2026.2708907. Online ahead of print.ABSTRACTIn recent years, pain has become a common and emergent complication in patients with β-thalassemia major. This systematic review investigates the assessment and management of pain in patients with β-thalassemia major. The Medline (via PubMed), Cochrane Library, and Web of Science databases were searched

Clin Cardiol. 2026 Aug;49(8):e70444. doi: 10.1002/clc.70444.ABSTRACTBACKGROUND/OBJECTIVES: Pain at the radial access site remains common during coronary angiography. Evidence on topical anesthesia with EMLA patches is inconsistent, and the added value of combining EMLA with local lidocaine infiltration has not been fully clarified. This study compared the analgesic effectiveness of three strategie

Cochrane Database Syst Rev. 2026 Aug 24;8:CD016383. doi: 10.1002/14651858.CD016383.ABSTRACTThis is a protocol for a Cochrane review (intervention). The objectives are as follows: To evaluate the benefits and harms of transcutaneous electrical nerve stimulation (TENS), used alone or as an adjunct to other interventions, compared with sham TENS, placebo, no treatment, or other clinical interventions

Cornea. 2026 Aug 4. doi: 10.1097/ICO.0000000000004262. Online ahead of print.ABSTRACTPURPOSE: To describe a new perilimbal subconjunctival botulinum toxin type A (BTX-A) injection technique and its outcomes in patients with refractory neuropathic corneal pain.METHODS: The procedure involves BTX-A injection into the nasal and temporal perilimbal subconjunctival spaces (10 units per site, 20 units t

Mol Pain. 2026 Jan-Dec;22:17448069261483479. doi: 10.1177/17448069261483479. Epub 2026 Aug 24.ABSTRACTChronic pain is accompanied by widespread physiological dysregulation, yet the mucosal immune system has received little attention. Salivary secretory-immunoglobulin-A (S-IgA) is a non-invasive biomarker of mucosal immunity modulated by sustained stress and autonomic activity. This cross-sectional

J Pain. 2026 Aug 23:106420. doi: 10.1016/j.jpain.2026.106420. Online ahead of print.ABSTRACTKinesiophobia plays a central role in understanding adult pain mechanisms, yet its assessment and theoretical relevance in pediatric pain remain poorly understood. Research to clarify the role of kinesiophobia in pediatric populations requires a valid and reliable measure of the construct. The most commonly