Genomics for chronic overlapping pain conditions
Published on November 3, 2026
Nat Rev Genet. 2026 Nov 2. doi: 10.1038/s41576-026-01029-y. Online ahead of print.
A wave of large genetic studies show that chronic pain conditions — long managed as separate, organ-specific and often unexplained disorders — share genetic risk concentrated in the nervous system. These findings give the concept of nociplastic pain a firmer biological footing and argue for studying and managing these conditions together rather than in specialty silos.
PMID:42972026 | DOI:10.1038/s41576-026-01029-y