Role of T Cells in Chronic Pain: Mechanisms, Regulation, and Therapeutic Implications

Published on September 7, 2026

Immunol Cell Biol. 2026 Sep 6. doi: 10.1111/imcb.70160. Online ahead of print.

ABSTRACT

T cells are critical for controlling the adaptive immune response and maintaining the homeostasis of the body. Recent evidence suggests that T cells are involved in the initiation, maintenance, and resolution of chronic pain by releasing mediators such as cytokines and endogenous opioids. In this review, we highlight recent advances in the involvement of T cells in chronic pain. We also describe how T cells act on sensory neurons to promote, suppress, or even resolve pain. Finally, we review how T cells are regulated and how we can translate these findings to develop therapies for chronic pain.

PMID:42702592 | DOI:10.1111/imcb.70160

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