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The Informational Blackout chronic pain and fatigue as rational outputs of a brain operating on degraded biological signals

August 27, 2026

Front Pain Res (Lausanne). 2026 Aug 12;7:1896306. doi: 10.3389/fpain.2026.1896306. eCollection 2026.ABSTRACTChronic pain and fatigue have resisted pharmacological resolution for two decades despite detailed mechanistic characterisation of nociceptive circuits. This perspective argues that the problem is not insufficient data but a mismatch between the level at which the dominant model operates and

The Informational Blackout chronic pain and fatigue as rational outputs of a brain operating on degraded biological signals

Notice of Correction to Reference Letters Due Date in PAR-27-026, "Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional)"