Efficacy of Platelet-Rich Plasma Injections Versus Corticosteroid Injections in the Management of Chronic Low Back Pain Secondary to Sacroiliitis
Pain Res Manag. 2026;2026(1):e8179046. doi: 10.1155/prm/8179046.
ABSTRACT
OBJECTIVES: Low back pain secondary to sacroiliitis (SI) significantly affects patients' quality of life. Although corticosteroid injections are commonly used, their effects may be temporary and have adverse effects. Platelet-rich plasma (PRP) has emerged as a potential alternative; however, comparative evidence remains limited. Therefore, this study aimed to compare the efficacy of PRP versus corticosteroid injections in managing chronic low back pain secondary to SI to provide evidence to guide clinical decision-making and optimize treatment strategies across different clinical contexts.
METHODS: This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 265 articles were identified in the databases, of which 4 met the defined inclusion and exclusion criteria. The search window was set to 2020-2025. The search window was limited to the past four years to capture recent and relevant evidence, given the field's rapid evolution.
RESULTS: Based on the selected articles, corticosteroids offer short-term relief, while PRP shows greater and longer-lasting benefits. Additionally, PRP was associated with a lower need for additional interventions and rescue analgesia, demonstrating a sustained effect over time.
CONCLUSIONS: Corticosteroids provide faster relief within 2-4 weeks, while PRP offers longer-lasting benefits from the eighth week up to 6 months. PRP also reduces the need for additional interventions and has no significant adverse effects, unlike corticosteroids. These findings suggest PRP as a safer long-term alternative for patients needing repeated or prolonged treatment. Future research should implement studies with a larger number of patients, longer observation periods, and follow-up to fully understand the benefits and limitations of both therapies.
PMID:42332419 | DOI:10.1155/prm/8179046