Effect of depression screening on future depressive symptoms in a persistent pain population: mediation analysis

Pain Rep. 2026 Jun 1;11(4):e1453. doi: 10.1097/PR9.0000000000001453. eCollection 2026 Aug.

ABSTRACT

INTRODUCTION: Clinical guidelines for persistent pain recommend screening for psychosocial factors. However, little is known about whether completing a structured depression questionnaire within a clinical encounter is associated with subsequent depressive symptom trajectories.

OBJECTIVE: To evaluate whether exposure to such a questionnaire is associated with depressive symptoms at 6-month follow-up, and, if so, whether the association remains after removing the effects of referral to, or engagement with, psychological care.

METHODS: We analysed clinical audit data from patients with persistent pain who were quasi-randomly allocated to complete full depression screening using the Patient Health Questionnaire-9 (PHQ-9) or a pain-knowledge questionnaire. The primary outcome was depressive symptoms at 6-month follow-up, using a validated single-item 0 to 10 mood rating scale. Causal mediation analysis estimated the direct effect of depression screening on follow-up mood by blocking effects of referral to, and engagement with, psychological care.

RESULTS: A total of 1779 participants (age [mean ± SD] = 42.7 ± 11.1 years; pain duration [mean ± SD] = 54.3 ± 29.9 months) were included. At 6-month follow-up, mood numerical rating scale scores improved in both groups (PHQ-9 group [n = 886] = -1.3 points [SD = 1.3]; pain-knowledge questionnaire group [n = 893] = -2.0 points [SD = 1.8]); the PHQ-9 group reported less improvement (mean difference = 0.7/10 points, 95% CI = 0.5-0.8). When referral for (n = 646) and engaging with psychological care (n = 466) were blocked, the direct effect remained (0.5/10 points, 95% CI = 0.3-0.6, 0.4/10 points, 95% CI = 0.2-0.6; respectively).

CONCLUSION: Exposure to screening had smaller reduction in depressive symptoms 6 months later than those who completed a pain-knowledge questionnaire, regardless of referral for, or engagement with, psychological care. Future research should examine how assessment processes influence patient sense-making, clinician responses, and referral pathways in pain care.

PMID:42238971 | PMC:PMC13229457 | DOI:10.1097/PR9.0000000000001453