When Dry Eye Is Pain: Frequency and Characteristics of a Pain Phenotype

Published on May 22, 2026

Ophthalmology. 2026 May 20:S0161-6420(26)00368-4. doi: 10.1016/j.ophtha.2026.05.020. Online ahead of print.

ABSTRACT

A pain-predominant phenotype was identified in 6.9% of patients diagnosed with dry eye disease, characterized by severe symptoms despite minimal signs, strong associations with migraine and psychiatric disorders, and lower prevalence of autoimmune conditions.

PMID:42167612 | DOI:10.1016/j.ophtha.2026.05.020

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