Notice of Early Expiration of PAR-25-202 "Technology Development Research for Establishing Feasibility and Proof of Concept (R21 - Clinical Trial Not Allowed)"

Published on May 12, 2026

Notice NOT-GM-26-005 from the NIH Guide for Grants and Contracts

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Targeting the HMGB1-TLR4 Axis Alleviates Neuropathic Pain-Associated Cognitive Deficits

May 11, 2026
J Neurosci. 2026 May 8:e2250252026. doi: 10.1523/JNEUROSCI.2250-25.2026. Online ahead of print.ABSTRACTCognitive deficits associated with chronic pain pose a significant burden on a patient's quality of life. Emerging evidence indicates that Toll-like receptor 4 (TLR4), a pattern recognition receptor implicated in neuroinflammatory signaling that can disrupt synaptic plasticity and memory processe

An Update on How NIH Protects NIH-Funded Research from Undue Foreign Interference

May 12, 2026
Protecting the integrity of NIH-funded research while supporting international collaboration remains a priority for NIH. Over the past year, we have advanced initiatives to strengthen transparency and ensure disclosure of other support. These actions align with White House Office of Science and Technology Policy (OSTP) standards and build on prior work to address risks associated with foreign inte