Notice of NINDS's Participation in PA-25-304: NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)

Published on April 9, 2026

Notice NOT-NS-26-009 from the NIH Guide for Grants and Contracts

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A µ-opioid receptor superagonist analgesic with minimal adverse effects

April 8, 2026
AbstractDeveloping safe and effective pain medications is an ongoing challenge for human health. Agonists for the µ-opioid receptor (MOR) are essential pain medications, but their high intrinsic efficacy also induces adverse side effects, including respiratory depression, constipation, tolerance, dependence, withdrawal and addiction. Strategies to limit adverse effects traditionally include develo

Is colorectal resection necessary to improve pain and fertility outcomes in patients with deep endometriosis?

April 9, 2026
Acta Obstet Gynecol Scand. 2026 Apr 8. doi: 10.1111/aogs.70212. Online ahead of print.ABSTRACTBowel endometriosis is often considered an indication for extensive surgical management, including colorectal resection, in women undergoing surgery for concomitant endometriosis at other sites. However, several contemporary studies show little or no correlation between the anatomical extent of bowel endo