Implementation of Changes for Basic Experimental Studies with Humans

Published on April 6, 2026

Notice NOT-OD-26-067 from the NIH Guide for Grants and Contracts

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Distinct effects of fibromyalgia pain, depression and anxiety on perception of affective touch and pain

April 6, 2026
J Physiol. 2026 Apr 4. doi: 10.1113/JP290243. Online ahead of print.ABSTRACTGentle stroking that activates C-tactile afferents is typically pleasant, calming and pain relieving. Deep pressure touch frequently elicits similar affective responses. However touch is often less pleasant for individuals with chronic pain. It is important to understand the reasons for this clinical difference because of

Cancer pain: current practice and emerging targets

April 6, 2026
Br J Pharmacol. 2026 Apr 3. doi: 10.1111/bph.70410. Online ahead of print.ABSTRACTCancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay o