Comparative Analysis of Topical vs. Systemic Analgesics for Pain Control During Initial Orthodontic Alignment
J Pharm Bioallied Sci. 2026 Jan-Mar;18(1):25-27. doi: 10.4103/jpbs.jpbs_1762_25. Epub 2026 Mar 12.
ABSTRACT
BACKGROUND: Pain associated with the initial bonding of fixed appliances and archwire insertion is a primary cause of non-compliance and treatment discontinuation in orthodontics. While systemic non-steroidal anti-inflammatory drugs (NSAIDs) are the gold standard for pain management, they are associated with systemic side effects and potential inhibition of tooth movement. Topical anesthetics offer a localized alternative, but their comparative efficacy against systemic analgesics during the initial alignment phase remains understudied.
MATERIALS AND METHODS: A randomized, double-blind, placebo-controlled clinical trial was conducted with 60 patients (mean age 16.4 ± 3.2 years) undergoing initial bonding with fixed appliances. Participants were randomly allocated into three groups (n = 20 each): Group A (Systemic Ibuprofen 400 mg), Group B (Topical 20% Benzocaine gel), and Group C (Placebo). Pain intensity was recorded using a Visual Analog Scale (VAS, 0-100 mm) at 2, 6, 24, 48, and 72 hours post-bonding.
RESULTS: Pain peaked at 24 hours across all groups. At the 24-hour interval, Group A reported the lowest mean pain scores (24.5 ± 12.3 mm), followed by Group B (41.2 ± 15.6 mm) and Group C (62.8 ± 18.1 mm). The difference between Group A and B was statistically significant (P < 0.05). However, Group B showed significantly lower pain scores compared to the placebo group at all time intervals up to 48 hours (P < 0.01). Rescue medication use was highest in Group C (45%) compared to Group A (5%) and Group B (15%).
CONCLUSION: While systemic ibuprofen remains superior for managing deep periodontal pain associated with initial alignment, topical benzocaine provides significant pain reduction compared to placebo and serves as a viable alternative for patients contraindicated for systemic NSAIDs.
PMID:41890381 | PMC:PMC13016145 | DOI:10.4103/jpbs.jpbs_1762_25