An Overview of Ischemic Preconditioning as a Potential Therapeutic Target for Chronic Muscle Pain
J Pain Res. 2026 Jan 13;19:546782. doi: 10.2147/JPR.S546782. eCollection 2026.
ABSTRACT
Chronic pain is a prevalent and highly disabling condition, affecting approximately 31% of the global population. Among its various forms, musculoskeletal disorders-particularly Myofascial Pain Syndrome (MPS)-account for a significant proportion. MPS is characterized by muscle spasms, localized ischemia, and pain, making it more easily diagnosable due to its distinct physical signs. Ischemic Preconditioning (IPC), a protective mechanism induced by brief cycles of ischemia followed by reperfusion, has demonstrated promising effects in studies involving cardiac and skeletal muscle tissues. Based on this, we hypothesize that cyclic compressive loading, which induces temporary local ischemia followed by reperfusion, may simulate the physiological effects of IPC. This approach could potentially alleviate ischemia-related muscle spasms and reduce chronic pain. To test this hypothesis, this paper begins with a review of the basic physiological mechanisms underlying ischemia and reperfusion injury, analyzing the relevant molecular pathways. It then systematically examines the protective effects of IPC in skeletal muscle, including the reduction of oxidative stress, suppression of inflammatory responses, and promotion of blood flow restoration. Furthermore, we compare the controllability and limitations of traditional massage, ischemic compression, and mechanically simulated IPC devices within therapeutic designs. In summary, this study provides theoretical support and a feasible framework for non-pharmacological interventions based on IPC mechanisms in the treatment of chronic muscular pain. It lays a foundational hypothesis for the development of standardized and scalable therapeutic devices, offering a stronger scientific basis for chronic pain management and presenting new strategies to address this growing public health challenge.
PMID:41858807 | PMC:PMC12998909 | DOI:10.2147/JPR.S546782