Introduction to the special issue on epigenetic regulation of chronic pain

Published on March 1, 2026

Pain Rep. 2026 Jan 20;11(2):e1406. doi: 10.1097/PR9.0000000000001406. eCollection 2026 Apr.

ABSTRACT

This Special Issue features 6 articles from leaders in the field that elucidate novel epigenetic mechanisms regulating nociception, inflammation, responses to pharmacologic and integrative therapies, and pain disparities among racial/ethnic groups. Together, they highlight the expanding potential of epigenomics to inform mechanistic discovery, guide personalized pain therapeutics, and advance pain equity.

PMID:41737924 | PMC:PMC12928944 | DOI:10.1097/PR9.0000000000001406

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