EEG-based quantification of chronic pain in cats: A proof-of-concept study using the Piq algorithm

Vet J. 2026 Feb 21;316:106608. doi: 10.1016/j.tvjl.2026.106608. Online ahead of print.

ABSTRACT

While chronic pain assessment in household pets remains challenging, the use of non-invasive electroencephalography (EEG) in cats has shown promise to identify pain more objectively in this species. A novel EEG-based algorithm - Pain identification and quantification (Piq) - was originally developed in humans to quantify pain intensity. In this proof-of-concept study, the objective was to evaluate whether the Piq algorithm could be explored for feasibility to identify and quantify chronic osteoarthritic (OA) pain in cats. Adult neutered cats (n = 5 including n = 2 with osteoarthritis, OA) were assessed for their functional impairment (Montreal instrument for cat arthritis testing for use by veterinarians, MI-CAT(V)) and neuro-sensitization at both peripheral (Paw Withdrawal Threshold, PWT) and spinal (response to mechanical temporal summation, RMTS) levels. Resting-state EEG recordings were acquired from Cz, C3/C4 under conscious and sedated conditions. The first five minutes of EEG data were analyzed using the Piq algorithm, with Piq scores ≥ 10 % used as an exploratory threshold transferred from human studies. Pain-free cats showed gamma frequency band Piq scores < 10 % while OA cats exceeded 10 % in both conscious and sedated conditions at Cz. Piq scores were negatively correlated with PWT, suggesting an increased neuro-sensitization with higher Piq scores. These preliminary findings suggest that the algorithm may capture gamma-band EEG patterns potentially associated with chronic OA pain in cats, consistent with prior evidence in humans. Despite the small sample size, this study demonstrates the feasibility of applying a human EEG-based pain quantification algorithm to OA cats, supporting its potential for future cross-species translation.

PMID:41724143 | DOI:10.1016/j.tvjl.2026.106608